Refractory: Not yielding, or not yielding readily, to treatment. To make his life easier, the store owner decided to fire the refractory workers who were difficult to manage. Definition and synonyms of refractory from the online English dictionary from Macmillan Education.. The relative refractory period refers to that period of time after the initiation of one action potential when it is … His session was dedicated to recognizing the various pathophysiologic processes that may contribute to refractory chronic rhinosinusitis (CRS) and to describing the available medical and treatment options. This definition was created based on the information from the REACH1 and REACH2 trials along with retrospective studies showing that 10–14 days was the median time to initial response following the start of ruxolitinib treatment in patients with steroid-refractory aGvHD. Author information: (1)Dartmouth Hitchcock Medical Center-Neurology, Lebanon, NH, USA. P. Kwan and M.J. Brodie, Early identification of refractory … Epub 2016 Oct 5. Refractories are inorganic, nonmetallic, porous, and heterogeneous. Properly diagnosed seizures do not respond to the best medical treatment. Refractory metals are a class of metals that are extraordinarily resistant to heat and wear.The expression is mostly used in the context of materials science, metallurgy and engineering.The definition of which elements belong to this group differs. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. MedicineNet does not provide medical advice, diagnosis or treatment. An International Working Group (IWG) defined refractory ITP as disease that does not respond to or relapses after splenectomy and that requires treatment to reduce the risk of clinically significant bleeding. In view of these issues, the term refractory ascites has often generated confusion in the past and made it difficult to compare the results of clinical studies performed by … Refractory and Intractable – The refractory is, when you’re reading the definitions, the one that is the best from medical terms is – resistant to treatment: a refractory case of acne. Several terms have been used to describe this condition, … TERMINOLOGY — The definition of refractory gastroesophageal reflux disease (GERD) is controversial . Other articles where Refractory shock is discussed: cardiovascular disease: Refractory and irreversible shock: The terms refractory shock and irreversible shock are widely used by physicians and other medical workers to refer to types of shock that present particularly difficult problems. (See "Medical management of gastroesophageal reflux disease in adults".) Definition of Refractory. Refractory bricks in a torpedo car used for hauling molten iron. For example: If the diagnosis is corrected and seizures can be brought under control with a different treatment, then they would not be considered refractory. See more. The term high temperatures is somewhat indefinite but usually means above about 1830°F (1000°C), or temperatures at which, because of melting or oxidation, the common metals cannot be used. Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based treatment. There are a number of reasons to attempt to define and classify refractory headache disorders. Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition. Definition of refractory adjective in Oxford Advanced Learner's Dictionary. Refractory. (1) To date, no randomized clinical trials examining the effects of HBO 2 therapy on A refractory material or refractory is a material that is resistant to decomposition by heat, pressure, or chemical attack, and retains strength and form at high temperatures. Refractory osteomyelitis is defined as a chronic osteomyelitis that persists or recurs after appropriate interventions have been performed or where acute osteomyelitis has not responded to accepted management techniques. This is the British English definition of refractory.View American English definition of refractory.. Change your default dictionary to American English. Started in 1995, this collection now contains 6856 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters. adj. Generally, migraines that are not relieved by acute migraine therapies or prevented by preventive treatments are called refractory migraines, although medical experts have not yet reached a consensus on a precise definition. Our paper aims to summarize the current medical literature on the conceptual and methodologic issues involved in the definition, assessment, and staging of TRD. Intensive Care Med. They are … not responsive or difficult to manage. home / medterms medical dictionary a-z list / anemia, refractory definition Not all uncontrolled seizures are considered refractory or drug resistant. 2016 Dec;42(12):1948-1957. doi: 10.1007/s00134-016-4574-2. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. The clinical manifestations, diagnosis, and initial medical management of GERD are discussed in detail separately. 1. Then, intractable, the one works best is highlighted in yellow – difficult to alleviate, remedy or cure: intractable pain. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. This means that the affected person continues to have seizures even when taking anti-seziure medications. In some cases, refractory migraine is used synonymously with chronic migraine, or referred to as intractable migraine. Learn more. Examples of Refractory in a sentence. Particularly important are the potential benefits in the areas of research, treatment, and medical cost reimbursement. The most common definition includes five elements: two of the fifth period (niobium … The generally accepted definition of refractory seizures was proposed by Berg: failure of two or more drugs and occurrence of one or more seizures per month over 18 months (2). 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